Twelve year old Remember Patience Whipple ("Mem" for short) has just arrived with her parents in the New World after a grueling 65 day journey on the Mayflower.
Mem has an irrepressible spirit, and leaps headfirst into life in her new home. Despite harsh conditions, Mem is fearless. She helps to care for the sick and wants more than anything to meet and befriend an Indian.
Her wish comes true when she meets Squanto, who helps Mem and her family face a year of trial, tragedy and thanksgiving.